Tag Archives: Neonates

Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation – a retrospective study

Although aminoglycosides are routinely used in neonates, controversy exists regarding empiric dosing regimens. The objectives of this study were to determine gentamicin pharmacokinetics in neonates, and develop initial mg/kg dosing recommendations that optimized target peak and trough concentration attainment for … Continue reading

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A nurturing programme on the neonatal surgical ward

A recently introduced nurturing programme on the neonatal surgical ward at Birmingham Children’s Hospital makes use of volunteer members of staff who sit with babies to provide comfort, cuddles and reassurance when the parents are not present. The initiative is … Continue reading

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Neonatal acute kidney injury: recording rate, course, and outcome: one center experience

Abstract Background: Neonates, and particularly preterm newborns, are at increased risk for acute kidney injury (AKI) due to immature kidney function. While specific criteria have been defined for AKI in this particular population, this diagnosis is frequently overlooked, and consequently, … Continue reading

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Cortisol intermediates and hydrocortisone responsiveness in critical neonatal disease

Abstract Objective: Therapy-resistant hypotension complicates diseases in neonates. Our objective was to investigate whether lack of therapeutic response to plasma expanders and inotropes associates with serum levels of cortisol and its precursors. Methods: We investigated 96 infants with hypotension and … Continue reading

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