Before birth the two main arteries connected to the heart are linked by a blood vessel called the ductus arteriosus, which is an essential part of foetal blood circulation. This vessel should close shortly after birth but sometimes doesn’t (patent ductus arteriosus) meaning blood rich in oxygen from the aorta mixes with blood poor in oxygen from the pulmonary artery. This can put strain on the heart and increase blood pressure in the lung’s arteries so doctors seal off the ductus arteriosus with a ligature. In this study Timothy J.B. Ulrich, from the Children’s Mercy Hospital in Kansas City, led a team of researchers looking into the complications of this operation (post-ligation cardiac syndrome). The team studied 100 babies who had the operation, 31 of whom went on to develop post-ligation cardiac syndrome (PLCS). PLCS was associated with an increased risk for severe bronchopulmonary dysplasia (BPD) and having to have home oxygen therapy but was not linked to eye problems (retinopathy of prematurity).
You can read the abstract of this article here.