Indomethacin is a non-steroidal anti-inflammatory drug sometimes given – for preventative (prophylactic) purposes – to extremely premature babies. In this study the medical records of 671 babies were analysed. 141 had not been given indomethacin while the rest had. The study found that the babies who had been given indomethacin were less likely to die, and were less likely to develop lung problems. However, there was no significant effect of prophylactic indomethacin on the incidence of severe intra-ventricular haemorrhage or patent ductus arteriosus ligation.
You can read the abstract of this article here.