Monthly Archives: August 2017

Premature birth and the microbiome

About one in 10 babies is born prematurely. Most premature births are due either to infection or unknown causes. Recently scientists have started to think that mothers’ microbiomes – the bacteria that live, with no ill effects on and within … Continue reading

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The value of serum pro-oxidant/antioxidant balance in the assessment of asphyxia in term neonates

Abstract Objective: Asphyxia is a major cause of disabilities in term-born infants. Here we have explored the value in HIE (hypoxic-ischemic-encephalopathy) of using a combination of serum pro-oxidant/antioxidant balance (PAB) assay for predicting the prognosis of asphyxia. Method: Ninety term … Continue reading

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Neonatal haemodynamic effects following foetal exposure to labetalol in hypertensive disorders of pregnancy

Abstract Objective: Hypertensive disorders of pregnancy (HDP) affect foetal outcome. Labetalol is frequently used to lower maternal blood pressure and prolong pregnancy. Conflicting evidence exists for specific neonatal side effects described after maternal labetalol treatment. Our aim was to investigate … Continue reading

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Cortisol intermediates and hydrocortisone responsiveness in critical neonatal disease

Abstract Objective: Therapy-resistant hypotension complicates diseases in neonates. Our objective was to investigate whether lack of therapeutic response to plasma expanders and inotropes associates with serum levels of cortisol and its precursors. Methods: We investigated 96 infants with hypotension and … Continue reading

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Significance of neutrophilic CD64 as an early marker for detection of neonatal sepsis and prediction of disease outcome

Abstract Background: Neonatal sepsis (NS) is a global health problem owing to its significant contribution to morbidity and mortality. We evaluated the significance of neutrophilic CD64 (nCD64) expression as an early marker for diagnosis of NS compared to CRP and … Continue reading

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Biomarkers for diagnosis of neonatal sepsis: a literature review

Abstract Sepsis is an important cause of mortality and morbidity in neonatal populations. There has been constant search of an ideal sepsis biomarker that have high sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), so that both … Continue reading

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Assessment of sickness severity of illness in neonates: review of various neonatal illness scoring systems

Abstract Sickness severity scores are widely used for neonates admitted to neonatal intensive care units to predict severity of illness and risk of mortality and long-term outcome. These scores are also used frequently for quality assessment among various neonatal intensive … Continue reading

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